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ARIMIDEX (anastrozole) tablets for oral administration contain 1 mg of anastrozole, a non-steroidal aromatase inhibitor. Anastrozole is an off-white powder with a molecular weight of 293.4. Anastrozole has moderate aqueous solubility (0.5 mg/mL at 25°C); solubility is independent of pH in the physiological range. Anastrozole is freely soluble in methanol, acetone, ethanol, and tetrahydrofuran, and very soluble in acetonitrile.
Each tablet contains as inactive ingredients: magnesium stearate, hydroxypropylmethylcellulose,lactose, polyethylene glycol, povidone, sodium starch glycolate, and titanium dioxide. It is chemically described as 1,3-Benzenediacetonitrile, a, a, a’, a’-tetramethyl-5- (1H-1,2,4-triazol-1-ylmethyl). Its molecular formula isC17H19N5 and its structural formula is |
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